Name : Arramshetti Venkanna
Paper title : Metal-Free a-C(sp3)¢H Functionalized Oxidative Cyclization of Tertiary N,N-Diarylamino Alcohols: Construction of N,N-Diarylaminotetrahydropyran Scaffolds
Affiliation : College of Pharmacy, Gachon University, South Korea
Country :
Paper Abstract : Herein, we report an efficient synthetic method
for the preparation of anomeric N,N-diarylaminotetrahydro-
pyran scaffolds. The free radical 2,2,6,6-tetramethyl-1-piperi-
dinyloxy (TEMPO)/hypervalent iodine(III)- or TEMPO/I2
-medi-
ated oxidative cyclization of tertiary amino alcohols was
used to construct N,N-diarylaminotetrahydropyrans through
a-C(sp3
)¢O bond formation, with the loss of only two
H atoms. This efficient synthetic method broadens the scope
of viable a-C(sp3
)¢H functionalized amines to include confor-
mational-bias-free substrates.
Conference Details : IRF International Conference,Hyderabad,25th Sept. 2016